IBG team receives ICGEB CRP grant for research on CENPA
IBG team receives ICGEB CRP grant for research on CENPA
The Transgenic Research Platform at the Izmir Biomedicine and Genome Center (IBG) has been awarded a three-year research grant under the Collaborative Research Programme (CRP) of the International Centre for Genetic Engineering and Biotechnology (ICGEB). The funded project will investigate how the phosphorylation of CENPA—a histone variant crucial for accurate chromosome segregation during cell division—is regulated through in vivo models.
Titled “In vivo investigation of the role of CENPA phosphorylation in mitosis,” the project aims to contribute to a deeper understanding of genetic control mechanisms at the cellular level. The research will be carried out in collaboration with Dr. Stefan Dimitrov from the Institute of Molecular Biology in Sofia, Bulgaria.
As part of the study, the team will utilize CRISPR/Cas9 genome editing technology to generate genetically modified mouse models carrying specific phospho-variants of CENPA. These models will enable detailed analysis of how these modifications influence centromere structure and function during mitosis.