Izmir Biomedicine and Genome Center

IBG-PHARMA

You can contact us directly for the services you request from IBG-Pharma.

Personnel

IBG-PHARMA

Platform Director

Mehmet İNAN
mehmet.inan@ibg.edu.tr
+90 232 299 41 00 (5271)
+9 0232 299 41 77

Sibel KALYONCU Analytical Development and Characterization Manager sibel.kalyoncu@ibg.edu.tr
+90 232 299 41 00 (5181)
0 (232) 299 41 68

Rıdvan ÖRKÜT R&D Personnel ridvan.orkut@ibg.edu.tr
+90 232 299 41 00 (4001)

Olcay MERT R&D Personnel olcay.mert@ibg.edu.tr
+90 232 299 41 00 (4001)

Hüseyin AKINTÜRK Research Technician huseyin.akinturk@ibg.edu.tr

Ayça ZEYBEK KUYUCU Researcher ayca.zeybekkuyucu@ibg.edu.tr

Muzaffer YILDIRIM Researcher muzaffer.yildirim@ibg.edu.tr

İbrahim Oğuzhan TARMAN Researcher oguzhan.tarman@ibg.edu.tr

Ceren ÖZER ÇOKGEZME PhD Student ceren.ozer@ibg.edu.tr

İrem KARACA MSc Student None

Erdem TÜRK PhD Student None

Tuğçe CANAVAR YILDIRIM Researcher tugce.yildirim@ibg.edu.tr

Hakan SOYTÜRK MSc Student hakan.soyturk@ibg.edu.tr

Doğu SAYILI Molecular Cell Biologist dogu.sayili@ibg.edu.tr

Latife Merve OKTAY ÇELEBİ Post-Doc Researcher latife.oktaycelebi@ibg.edu.tr

Şeyda GÜLLÜ Researcher seyda.gullu@ibg.edu.tr

Mert ABAY Researcher mert.abay@ibg.edu.tr

Ali Mert SENCER PhD Student mert.sencer@ibg.edu.tr

Ender AVCI Researcher ender.avci@ibg.edu.tr
+90 232 299 41 00 (2501)
0 (232) 299 4191

Former Personnel

Tuğçe BATUR Research Assistant tugce.batur@ibg.edu.tr

Rıdvan ÖRKÜT R&D Personnel ridvan.orkut@ibg.edu.tr
+90 232 299 41 00 (4001)

Gizem YILMAZER ALTUN R&D Personnel gizem.yilmazer@ibg.edu.tr

Umut EKİN Research Assistant umut.ekin@ibg.edu.tr

Olcay MERT R&D Personnel olcay.mert@ibg.edu.tr
+90 232 299 41 00 (4001)

Cemre YAŞAR Research Technician cemre.yasar@ibg.edu.tr

Hasan Onur ÇAĞLAR Post-Doc Researcher hasan.caglar@msfr.ibg.edu.tr

Gizem BOSKAN PhD Student gizem.boskan@msfr.ibg.edu.tr

Mehmet Can UÇAR Undergraduate Student can.ucar@msfr.ibg.edu.tr

Semiramis YILMAZ Researcher semiramis.yilmaz@ibg.edu.tr

Vedat SARI Undergraduate Student vedat.sari@ibg.edu.tr

Şeyda GÜLLÜ MSc Student seyda.gullu@ibg.edu.tr

Bilgünay İlkin SAFA Undergraduate Student ilkin.safa@ibg.edu.tr

Gizem ARIK Post-Doc Researcher gizem.arik@msfr.ibg.edu.tr

Bahriye KARAKAŞ KÖSE Post-Doc Researcher bahriye.karakas@ibg.edu.tr

Sıla KAHYAOĞLU Visiting Researcher sila.kahyaoglu@ibg.edu.tr

Ceren ÖZER ÇOKGEZME Researcher ceren.ozer@ibg.edu.tr

Büşra LULACİ Technician busra.lulaci@ibg.edu.tr

Fatih MAMAK Undergraduate Student fatih.mamak@ibg.edu.tr

Erhan ÇITAK MSc Student erhan.citak@msfr.ibg.edu.tr

Ayça URAS MSc Student None

Selected Publications

Kalyoncu S, Yilmaz S, Kuyucu AZ, Sayili D, Mert O, Soyturk H, Gullu S, Akinturk H, Citak E, Arslan M, Taskinarda MG, Tarman IO, Altun GY, Ozer C, Orkut R, Demirtas A, Tilmensagir I, Keles U, Ulker C, Aralan G, Mercan Y, Ozkan M, Caglar HO, Arik G, Ucar MC, Yildirim M, Yildirim TC, Karadag D, Bal E, Erdogan A, Senturk S, Uzar S, Enul H, Adiay C, Sarac F, Ekiz AT, Abaci I, Aksoy O, Polat HU, Tekin S, Dimitrov S, Ozkul A, Wingender G, Gursel I, Ozturk M, Inan M. Process development for an effective COVID-19 vaccine candidate harboring recombinant SARS-CoV-2 delta plus receptor binding domain produced by Pichia pastoris.. Scientific reports. 2023 March ; 13 (1) : 5224. doi:10.1038/s41598-023-32021-9. Download

Erden-Karaoğlan F, Karaoğlan M, Yılmaz G, Yılmaz S, İnan M. Deletion analysis of Pichia pastoris alcohol dehydrogenase 2 (ADH2) promoter and development of synthetic promoters.. Biotechnology journal. 2022 February ; 17 (2) : e2100332. doi:10.1002/biot.202100332. Download

Karaoğlan M, Erden-Karaoğlan F, Yılmaz S, İnan M. Identification of major ADH genes in ethanol metabolism of Pichia pastoris.. Yeast. 2020 February ; 37 (2) : 227-236. doi:10.1002/yea.3443. Download

Erden-Karaoğlan F, Karakaş-Budak B, Karaoğlan M, Inan M. Cloning and expression of pullulanase from Bacillus subtilis BK07 and PY22 in Pichia pastoris.. Protein expression and purification. 2019 October ; 162 : 83-88. doi:10.1016/j.pep.2019.05.008. Download

Türkanoğlu Özçelik A, Ersöz F, İnan M. Extracellular production of the recombinant bacterial transglutaminase in Pichia pastoris.. Protein expression and purification. 2019 July ; 159 : 83-90. doi:10.1016/j.pep.2019.03.003. Download

Ersöz F, İnan M. Large-scale production of yak (Bos grunniens) chymosin A in Pichia pastoris.. Protein expression and purification. 2019 February ; 154 : 126-133. doi:10.1016/j.pep.2018.10.007. Download

Türkanoǧlu Özçelik A, Yılmaz S, Gökbora S, İnan M. A quantitative polymerase chain reaction assay for the detection of equine (horse and donkey)-originated meat in processed bovine meat products.. Food science and technology international = Ciencia y tecnologia de los alimentos internacional. 2019 January ; 25 (1) : 38-46. doi:10.1177/1082013218794849. Download

Karaoglan M, Erden Karaoglan F. and Inan M.. Functional analysis of alcohol dehydrogenase (ADH) genes in Pichia pastoris. Biotechnol Lett. 2016 March ; 38 (3) : 463-9. doi:10.1007/s10529-015-1993-z. Download

Karaoglan M, Karaoglan FE, Inan M. Comparison of ADH3 promoter with commonly used promoters for recombinant protein production in Pichia pastoris. Protein Expr Purif. 2016 May ; 121 : 112-7. doi:10.1016/j.pep.2016.01.017. Download

Khasa YP, Conrad S, Sengul M, Plautz S, Meagher MM, Inan M. Isolation of Pichia pastoris PIR genes and their utilization for cell surface display and recombinant protein secretion. Yeast. 2011 March ; 28 (3) : 213-26. doi:10.1002/yea.1832. Download

Jacobs PP, Inan M, Festjens N, Haustraete J, Van Hecke A, Contreras R, Meagher MM, Callewaert N. Fed-batch fermentation of GM-CSF-producing glycoengineered Pichia pastoris under controlled specific growth rate. Microb Cell Fact. 2010 November ; 9 : 93. doi:10.1186/1475-2859-9-93. Download

Kane J, Inan M and Saraf R.F. Self-Assembled Nanoparticle Necklaces Network Showing Single-Electron Switching at Room Temperature and Biogating Current by Living Microorganisms. ACS Nano. 2010 ; 4 (1) : 317–323. doi:10.1021/nn901161w. Download

Total : 12

Selected Book Chapters

Pichia pastoris Promoters (2019). Recombinant Protein Production in Yeast. Humana Press, New York, NY.

Total : 1

Projects

The Scientific and Technological Research Council of Turkey - TUBITAK - RD : Target Specific Pan-Cancer Therapies (PAN-TER), Ongoing

The Scientific and Technological Research Council of Turkey - TUBITAK - RD : Development of Pichia pastoris Expression Strains for Large Scale Biopharmaceutical Production via Metabolic Engineering Tools, Ongoing

European Union - Infrastructure : RareBoost - Boosting the Rare Disease research and innovation capacity of the Izmir Biomedicine and Genome Center, Ongoing

The Scientific and Technological Research Council of Turkey - TUBITAK - RD : Development of Recombinant Protein Based Vaccine Against SARS-CoV-2, Ongoing

The Scientific and Technological Research Council of Turkey - TUBITAK - RD : Development of Drugs Based on “Ghost Receptor-Antibody” Against SARS-CoV-2, Ongoing

Patents

Danielle Marie Mitchell, Leon F. Garcia-Martinez, Patricia Dianne McNeill, Ethan Wayne Ojala, Mehmet Inan,John Latham 2022 , Multi-copy strategy for high-titer and high-purity production of multi-subunit proteins such as antibodies in transformed microbes such as Pichia pastoris, US11225667B2
Mitchell, D.M., Garcia-Martinez, L.F., McNeill, P.D., Ojala, E.W., Inan, M. and Latham, J. 2018 , Multi-copystrategy for high-titer and high-purity production of multi-subunit proteins such as antibodies in transformed microbes such as Pichia pastoris, US10150968B2
Mehmet İNAN 2010 , PiPichia pastoris PIR1 secretion signal peptide for recombinant protein expression and Pichia pastoris PIR1 and PIR2 anchor domain peptides for recombinant surface display, US7741075B2
Mehmet Inan, Michael M. Meagher Andrew K. Benson 2004 , Alcohol oxidase 1 regulatory nucleotide sequences for heterologous gene expression in yeast, US6699691B2

Contact

IBG-PHARMA

Platform Director

Mehmet İNAN
mehmet.inan@ibg.edu.tr
+90 232 299 41 00 (5271)
+9 0232 299 41 77