The study by IBG researchers offers a new perspective on liver cancer
The study by IBG researchers offers a new perspective on liver cancer
The identification of novel fusion transcripts involved in hepatocellular carcinoma (HCC) is the focus of a recent study coordinated by Dr. Yasemin Öztemur Islakoğlu, a researcher at the İzmir Biomedicine and Genome Center (IBG). The project, titled "Discovery of Novel Fusion Transcripts Associated with Hepatocellular Carcinoma through a Systems Biology Approach and Investigation of Their Roles in Hepatocarcinogenesis", was carried out under the mentorship of Prof. Dr. Neşe Atabey and Prof. Dr. Gökhan Karakülah, and supported by the TÜBİTAK 2218 – Postdoctoral Research Fellowship Program. The results have been published in the journal RNA Biology.
The article, titled "Fusion transcripts landscape in hepatocellular carcinoma and potential impact on the expression of fusion partners" was selected as one of 13 studies to be featured as part of the Translational Control in Cancer European Network (TRANSLACORE) collection.
This multidisciplinary and multi-institutional study involved contributions from IBG researchers Prof. Dr. Neşe Atabey, Prof. Dr. Gökhan Karakülah, Dr. Yasemin Öztemur Islakoğlu, and Dr. Ezgi Bağırsakçı; Dr. Peyda Korhan from İzmir Tınaztepe University; Prof. Dr. Emine Şamdancı and Dr. Meryem Uludağ Taşçıoğlu from İnönü University; and Barış Keleş and Leman Binokay, students at Dokuz Eylül University IBG-Izmir Institute.
Presenting a comprehensive profile of tumor-specific, previously undescribed fusion transcripts in hepatocellular carcinoma, this study is the first to highlight the potential of these molecules for use in early diagnosis, disease monitoring, and the development of personalized therapeutic approaches.
https://doi.org/10.1080/15476286.2025.2529036