To date, there is a substantial amount of data in the literature analyzing the EMT program both during embryonic development and also during tumorigenesis, but a similar understanding of the MET program is still lagging. Recently we have identified a feed forward loop, which is composed of the transcription factors Grhl3 and Hnf4a that is essential for the progression of MET. In fact, Grhl3 emerged as an absolute requirement for the initiation of MET. Cells lacking Grhl3 as a result of RNAi-mediated knockdown failed to initiate the MET program. This is in part due to their inability to upregulate E-cad expression. Furthermore, we found that Grhl3 contributes to the regulation of Hnf4α by binding to a well-conserved motif present within the Hnf4α promoter P2. We believe that there is a need to gather more credible scientific evidence that answers key questions regarding how the process of MET is regulated, how it is initiated and the transcription factors involved in this regulation.
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