Atabey Lab. on Cancer Biology and Signaling

Overview

Atabey Lab. has been working in the field of Cancer Biology and Signaling. The scientific goal of our group is to fill the gaps in the fundamental biological mechanisms underlying the development and progression of cancer. Over the past two decades, our group has been working on to develop deeper understanding the role of signal transduction cascade in cancer development and progression and using this molecular knowledge to improve the diagnosis and treatment of cancer.

Specific Goals

1) Identification of the potential reciprocal crosstalk between c-Met receptor and other signaling molecules and their cooperative interaction in drug resistance in HCC
2) Investigating HGF/c-Met axis in tumor microenvironment and metastasis formation in the liver
3) Identification of the potential reciprocal crosstalk between HGF/c-Met signaling and glucose metabolism in HCC using various in vitro and in vivo models and further use this knowledge for developing strategies to prevent HCC
4) Identification of the roles of non-coding RNAs in the regulation of c-Met signaling in HCC
5) Deciphering signaling pathways in clinical samples for precision medicine using omics technologies
6) The use of omics data obtaining by our group and by the literature to investigate signaling mechanisms in metastasis and cancer by using in silico methods
7) Fabrication and validation of Lab-on-a-chip (LOC) system to predict metastatic and invasive ability to circulating tumor cells
8) Application of LOC in the early stage of anti-metastatic drug discovery focusing on gene expressions, receptor signaling and susceptibility

Our Team

Peyda Korhan, Research Associate
BSc (1998-2002); Thrace University, Biology
MSc (2003-2005); University of Wolverhampton UK, Biomedical Science
PhD (2007- 2014); Dokuz Eylül University, Medical Biology and Genetics

Yasemin Öztemur Islakoğlu, Post-Doctoral Researcher
BSc (2007-2011); Hacettepe University, Biology
MSc (2011-2013); Ankara University Biotechnology Institute, Basic Biotechnology
PhD (2014-2018); Ankara University Biotechnology Institute, Basic Biotechnology

Yeliz Yılmaz, PhD candidate
BSc (2004-2008); Boğaziçi University, Molecular Biology and Genetics
MSc (2008-2011); Boğaziçi University, Molecular Biology and Genetics

Ezgi Bağırsakçı, PhD candidate
BSc (2009 – 2014); İhsan Doğramacı Bilkent University, Molecular Biology and Genetics
MSc (2015-2017); Dokuz Eylül University, Medical Biology and Genetics

Dehan Çömez, MSc candidate
BSc (2010-2014); İstanbul University, Molecular Biology and Genetics

Gülsün Bağcı, MSc candidate
BSc (2012-2016); Izmir Institute of Technology (IZTECH), Molecular Biology and Genetics

Alumni

Hande Topel, Post-Doctoral Researcher, University of Southern Denmark (SDU)
BSc (2004–2008); Ege University, Biology
MSc (2008-2011); Dokuz Eylül University, Histology and Embryology
PhD (2013- 2019); Dokuz Eylül University, Molecular Biology and Genetics

Group Members

Atabey Lab. on Cancer Biology and Signaling

Group Leader

Safiye Nese ATABEY
nese.atabey@ibg.edu.tr
+90 232 299 41 00 (5221)
+9 02322994172

Peyda Korhan Research Associate peyda.korhan@ibg.edu.tr

Yeliz Yılmaz PhD Student yeliz.yilmaz@ibg.edu.tr

Dehan Çömez MSc Student dehan.comez@ibg.edu.tr

Gülsün Bağcı MSc Student gulsun.bagci@msfr.ibg.edu.tr

Yasemin Öztemur Islakoğlu Post-doc yasemin.oztemur@ibg.edu.tr

Ezgi Bağırsakçı PhD Student ezgi.bagirsakci@msfr.ibg.edu.tr

Selected Publications

Aysim Gunes, Ezgi Bagirsakci, Evin Iscan, Gulcin Cakan-Akdogan, Umut Aykutlu, Serif Senturk, Gunes Ozhan, Esra Erdal, Deniz Nart, Funda Yilmaz Barbet, Nese Atabey. Thioredoxin interacting protein promotes invasion in hepatocellular carcinoma. Oncotarget. 2018 ; 9 (96): 36849-36866. doi:10.18632/oncotarget.26402.

İşcan E, Güneş A, Korhan P, Yılmaz Y, Erdal E, Atabey N. The regulatory role of heparin on c-Met signaling in hepatocellular carcinoma cells. J Cell Commun Signal. 2017 Jun ; 11 (2): 155-166. doi:10.1007/s12079-016-0368-0.

Firtina Karagonlar Z, Koç D, Şahin E, Avci ST, Yilmaz M, Atabey N, Erdal E. Effect of adipocyte-secreted factors on EpCAM+/CD133+ hepatic stem cell population.. Biochemical and biophysical research communications. 2016 Jan ; 474 (3): 482-490. doi:10.1016/j.bbrc.2016.04.137.

Firtina Karagonlar Z, Koc D, Iscan E, Erdal E, Atabey N. Elevated hepatocyte growth factor expression as an autocrine c-Met activation mechanism in acquired resistance to sorafenib in hepatocellular carcinoma cells.. Cancer science. 2016 Jan ; 107 (4): 407-16. doi:10.1111/cas.12891.

Gunes A, Iscan E, Topel H, Avci ST, Gumustekin M, Erdal E, Atabey N. Heparin treatment increases thioredoxin interacting protein expression in hepatocellular carcinoma cells.. The international journal of biochemistry & cell biology. 2015 Jan ; 65 169-81. doi:10.1016/j.biocel.2015.05.025.

Korhan P, Erdal E, Kandemiş E, Cokaklı M, Nart D, Yılmaz F, Can A, Atabey N. Reciprocal activating crosstalk between c-Met and caveolin 1 promotes invasive phenotype in hepatocellular carcinoma.. PloS one. 2014 Jan ; 9 (8): e105278. doi:10.1371/journal.pone.0105278.

Korhan P, Erdal E, Atabey N. MiR-181a-5p is downregulated in hepatocellular carcinoma and suppresses motility, invasion and branching-morphogenesis by directly targeting c-Met.. Biochemical and biophysical research communications. 2014 Jan ; 450 (4): 1304-12. doi:10.1016/j.bbrc.2014.06.142.

Kunter I, Erdal E, Nart D, Yilmaz F, Karademir S, Sagol O, Atabey N. Active form of AKT controls cell proliferation and response to apoptosis in hepatocellular carcinoma.. Oncology reports. 2014 Jan ; 31 (2): 573-80. doi:10.3892/or.2013.2932.

Bozkaya G, Korhan P, Cokaklı M, Erdal E, Sağol O, Karademir S, Korch C, Atabey N. Cooperative interaction of MUC1 with the HGF/c-Met pathway during hepatocarcinogenesis.. Molecular cancer. 2012 Jan ; 11 64. doi:10.1186/1476-4598-11-64.

Gumustekin M, Kargi A, Bulut G, Gozukizil A, Ulukus C, Oztop I, Atabey N. HGF/c-Met overexpressions, but not met mutation, correlates with progression of non-small cell lung cancer.. Pathology oncology research : POR. 2012 Jan ; 18 (2): 209-18. doi:10.1007/s12253-011-9430-7.

Ozen E, Gozukizil A, Erdal E, Uren A, Bottaro DP, Atabey N. Heparin inhibits Hepatocyte Growth Factor induced motility and invasion of hepatocellular carcinoma cells through early growth response protein 1.. PloS one. 2012 Jan ; 7 (8): e42717. doi:10.1371/journal.pone.0042717.

Cokakli M, Erdal E, Nart D, Yilmaz F, Sagol O, Kilic M, Karademir S, Atabey N. Differential expression of Caveolin-1 in hepatocellular carcinoma: correlation with differentiation state, motility and invasion.. BMC cancer. 2009 Jan ; 9 65. doi:10.1186/1471-2407-9-65.

Projects

Tubitak - RD : METASTAZIN ERKEN TANISINDA YENİ BİR YONGA ÜSTÜ LABORATUVAR (LAB ON A CHIP; LOC) CİHAZI , 2015-10-15/2019-04-15

Tubitak - RD : YÜKSEK GLUKOZ ARACILIKLI HEPATOSELLÜLER KARSİNOMA PROGRESYONUNUN MOLEKÜLER MEKANİZMASI: C-MET AKTİVASYONU VE YENİ ADAYLAR THİOREDOXİN INTERACTİNG PROTEİN, SESTRİN2, VE INCRNA HOTAIR , 2014-10-15/2017-04-15

Contact

Atabey Lab. on Cancer Biology and Signaling

Group Leader

Safiye Nese ATABEY
nese.atabey@ibg.edu.tr
+90 232 299 41 00 (5221)
+9 02322994172