Cetin Lab.

OVERVIEW

The process of developing biosensors requires fundamental research on plasmonics so that new functionalities can be achieved that are not available with the conventional approaches. In Nanophotonics and Biodetection Systems Laboratory, we utilize nano-plasmonics to develop ultra-sensitive spectroscopy and sensing technologies for real-time, label-free and high-throughput detection and analysis of very low quantities of biomolecules. In order to achieve large sensitivities, high-quality factor plasmonic structures supporting extremely sharp spectral features with strong nearfield responses are explored. The sensing platforms utilizing these plasmonic structures allows stronger analyte-field overlap, which leads strong spectroscopy and sensing signals, easily distinguishable by detectors.

RESEARCH HIGHLIGHTS

PLASMONIC HAND-HELD BIOSENSORS FOR FIELD SETTINGS
In the conventional spectrometer-based read-out schemes that utilize refractive index sensing, the presence of biomolecules is measured by monitoring spectral shifts within the optical response of the plasmonic structures. These platforms can enable analyte sensing, i.e., viruses or bacteria, from biological media at clinically relevant concentrations with little to no sample preparation. Multiplexing and high-throughput capability of these biosensors can be improved via integrating large scale and highly dense plasmonic chips to imaging based platforms, i.e., CCD or CMOS cameras. These biosensors can be also portable to be employed in the resource-poor settings by integrating plasmonic chip technology with lensfree telemedicine technology. This handheld design can be integrated with portable read-out-devices, e.g., a laptop or a cell-phone, that enables detection of biomolecules with a multiplexed manner in any environment, lack of medical infrastructure. This system can also enable parallel detection of different biomolecules with ultra-thin layers as well as quantitative analyses of single-type biomolecules with large variety of concentrations. We also investigate fluidic systems integrated with plasmonic chip technology for efficient analyte-delivery, yielding ultra-fast sensor response. Integrating microfluidics with plasmonic handheld technology, we also demonstrate real-time analyses of protein-protein interaction kinetics in a cost-effective and high-throughput manner. Utilizing robust and smart algorithms, this microfluidic technology allows to monitor biomolecular binding interactions at pMolar levels.

Personnel

Cetin Lab.

Director

ARIF ENGIN ÇETİN
arifengin.cetin@ibg.edu.tr
+90 232 299 41 00 (5161)
+9 02322994166

ECE CESUR Biomedical Engineer  ece.cesur@ibg.edu.tr


BİLGE CAN Visiting Researcher  bilge.can@msfr.ibg.edu.tr


ŞEVİN AY MSc Student  sevin.ay@msfr.ibg.edu.tr


Selected Publications

Arif E. Cetin, Cihan Yilmaz, Betty C. Galarreta, Gizem Yilmaz, Hatice Altug and Ahmed Busnaina. Fabrication of Sub-10 nm Plasmonic Gaps for Ultra-Sensitive Raman Spectroscopy. PLASMONICS. 2020 February. doi:10.1007/s11468-020-01137-3.

Arif E. Cetin. Effect of Left handed Materials in Surface Plasmon Excitation and Propagation Length. Turkish Journal of Physics. 2019 February; 43: 26-36. doi:10.3906/fiz-1804-9.

Arif E. Cetin, and Seda Nur Topkaya. Photonic Crystal and Plasmonic Nanohole Based Label-Free Biodetection. Biosensors & Bioelectronics. 2019 May; 132: 196-202. doi:10.1016/j.bios.2019.02.047.

Seda Nur Topkaya, and Arif E. Cetin. Determination of Electrochemical Interaction Between 2‐(1H‐benzimidazol‐2‐yl) Phenol and DNA Sequences. ELECTROANALYSIS. 2019 August; 31 (8): 1554-1561. doi:10.1002/elan.201900199.

Habibe Durmaz, Arif E Cetin, Yuyu Li, and Roberto Paiella. A Polarization Insensitive Wide-Band Perfect Absorber. ADVANCED ENGINEERING MATERIALS. 2019 August; 21 (8): 1900188. doi:10.1002/adem.201900188.

Seda Nur Topkaya and Arif E. Cetin. Investigation of Metal Ion Effect on Specific DNA Sequences and DNA Hybridization. Electroanalysis. 2019 August; 31: 1-8. doi:10.1002/elan.201900391.

Arif E. Cetin, and Seda Nur Topkaya. Plasmonic Diffraction Field Pattern Imaging Could Resolve Ultra-Sensitive Bio-Information. ACS PHOTONICS. 2019 November; 6 (11): 2626-2635. doi:10.1021/acsphotonics.9b01076.

Yasa Eksioglu, Arif E. Cetin, and Habibe Durmaz. Multi-Band Plasmonic Platform Utilizing UT-Shaped Graphene Antenna Arrays. PLASMONICS. 2018 June; 13 (3): 1081–1088. doi:10.1007/s11468-017-0607-0.

Seda Nur Topkaya, Vasfiye Hazal Ozyurt, Arif E. Cetin, and Semih Otles. Nitration of Tyrosine and Its Effect on DNA Hybridization. BIOSENSORS & BIOELECTRONICS. 2018 April; 102: 464-469. doi:10.1016/j.bios.2017.11.061.

Arif E. Cetin, Pinar Iyidogan, Yuki Hayashi, Mark Wallen, Kandaswamy Vijayan, Eugene Tu, Mike Nguyen, and Arnold Oliphant. Plasmonic Sensor Could Enable Label-Free DNA Sequencing. ACS SENSORS. 2018 February; 3 (3): 561-568. doi:10.1021/acssensors.7b00957.

Habibe Durmaz, Yuyu Li, and Arif E. Cetin. A Multiple-Band Perfect Absorber for SEIRA Applications. Sensors and Actuators B: Chemical. 2018 December; 275: 174-179. doi:10.1016/j.snb.2018.08.053.

Ahmet F. Coskun, Seda Nur Topkaya, Ali K. Yetisen, and Arif E. Cetin. Portable Multiplex Optical Assays. Advanced Optical Materials. 2018 December; 7 (4): 1801109. doi:10.1002/adom.201801109.

Arif E. Cetin, Mark Stevens, Nicholas Calistri, Mariateresa Fulciniti, Selim Olcum, Robert Kimmerling, Nikhil Munshi, and Scott Manalis. Determining Therapeutic Susceptibility in Multiple Myeloma by Single-Cell Mass Accumulation. NATURE COMMUNICATIONS. 2017 November; 8 (1613): 1-12. doi:10.1038/s41467-017-01593-2.

Miquel Rudé, Vahagn Mkhitaryan, Arif E. Cetin, Timothy A. Miller, Albert Carrilero, Simon Wall, F. Javier García de Abajo, Hatice Altug, and Valerio Pruneri. Ultrafast and broadband tuning of resonant optical nanostructures using phase-change materials. ADVANCED OPTICAL MATERIALS. 2016 May; 4 (7): 1060-1066. doi:10.1002/adom.201600079.

Arif E. Cetin, Martin Drsata, Yasa Eksioglu, and Jiri Petracek. Extraordinary Transmission Characteristics of Subwavelength Nanoholes with Rectangular Lattice. PLASMONICS. 2016 June; 12 (3): 655-661. doi:10.1007/s11468-016-0311-5.

Arif E. Cetin, Semih Korkmaz, Habibe Durmaz, Ekin Aslan, Sabri Kaya, Roberto Paiella, and Mustafa Turkmen. Quantification of Multiple Molecular Finger-Prints by Dual-Resonant Perfect Absorber. ADVANCED OPTICAL MATERIALS. 2016 August; 4 (8): 1274-1280. doi:10.1002/adom.201600305.

Arif E. Cetin, Sabri Kaya, Alket Mertiri, Ekin Aslan, Shyamsunder Erramilli, Hatice Altug, and Mustafa Turkmen. Dual-Band Plasmonic Resonator based on Jerusalem Cross-Shaped Nanoapertures. PHOTONICS AND NANOSTRUCTURES-FUNDAMENTALS AND APPLICATIONS. 2015 June; 15: 73-80. doi:10.1016/j.photonics.2015.04.001.

Arif E. Cetin, Serap Aksu, Mustafa Turkmen, Dordaneh Etezadi, and Hatice Altug. Theoretical and Experimental Analysis of Subwavelength Bowtie-Shaped Antennas. JOURNAL OF ELECTROMAGNETIC WAVES AND APPLICATIONS. 2015 July; 29 (13): 1686-1698. doi:10.1080/09205071.2015.1051188.

Arif E. Cetin, Dordaneh Etezadi, Betty Galarreta, Mickael P. Busson, Yasa Eksioglu, and Hatice Altug. Plasmonic Nanohole Arrays on a Robust Hybrid Substrate for Highly Sensitive Label-Free Biosensing. ACS PHOTONICS. 2015 July; 2 (8): 1167-1174. doi:10.1021/acsphotonics.5b00242.

Yasa Eksioglu, Arif E. Cetin, and Jiri Petracek. Optical Response of Plasmonic Nanohole Arrays: Comparison of Square and Hexagonal Lattices. PLASMONICS. 2015 October; 11 (3): 851–856. doi:10.1007/s11468-015-0118-9.

Cihan Yilmaz, Arif E. Cetin, Georgia Goutzamanidis, Jun Huang, Sivasubramanian Somu, Hatice Altug, Dongguang Wei, and Ahmed Busnaina. “Three-dimensional Crystalline and Homogeneous Metallic Nanostructures Using Directed-Assembly of Nanoparticles. ACS NANO. 2014 April; 8 (5): 4547-4558. doi:10.1021/nn500084g.

Arif E. Cetin, Dordaneh Etezadi, and Hatice Altug. Accessible Nearfields by Nanoantennas on Nanopedestals for Ultrasensitive Vibrational Spectroscopy. ADVANCED OPTICAL MATERIALS. 2014 June; 2 (9): 866-872. doi:10.1002/adom.201400171.

Ahmet F. Coskun, Arif E. Cetin*, Betty C. Galarreta, Daniel Adrianzen Alvarez, Hatice Altug, and Aydogan Ozcan. Lensfree Optofluidic Plasmonic Sensor for Real-Time and Label-Free Monitoring of Molecular Binding Events over a Wide Field-of-Wiew. SCIENTIFIC REPORTS. 2014 October; 4 (6789): 1-7. doi:10.1038/srep06789.

Arif E. Cetin. FDTD Analysis of Optical Forces on Bowtie Antennas for High-Precision Trapping of Nanostructures. INTERNATIONAL NANO LETTERS. 2014 November; 5 (1): 21–27. doi:10.1007/s40089-014-0132-5.

Arif E. Cetin*, Mustafa Turkmen, Serap Aksu, Dordaneh Etezadi, and Hatice Altug. Multi-Resonant Compact Nanoaperture with Accessible Large Nearfields. APPLIED PHYSICS B-LASERS AND OPTICS. 2014 October; 118 (1): 29-38. doi:10.1007/s00340-014-5950-7.

Arif E. Cetin, Ahmet F. Coskun, Betty C. Galarreta, Min Huang, David Herman, Aydogan Ozcan, and Hatice Altug. Handheld High-Throughput Plasmonic Biosensor using Computational On-Chip Imaging. LIGHT-SCIENCE & APPLICATIONS. 2014 January; 3 (e122): 1-10. doi:10.1038/lsa.2014.3.

Serap Aksu, Arif E. Cetin, Ronen Adato, and Hatice Altug. Plasmonically Enhanced Vibrational Biospectroscopy Using Low-Cost Infrared Antenna Arrays by Nanostencil Lithography. ADVANCED OPTICAL MATERIALS. 2013 November; 1 (11): 798-803. doi:10.1002/adom.201300133.

Min Huang, Betty C. Galarreta, Arif E. Cetin, and Hatice Altug. Actively Transporting Virus Like Analytes with Optofluidics for Rapid and Ultrasensitive Biodetection. LAB ON A CHIP. 2013 September; 13 (24): 4841-4847. doi:10.1039/C3LC50814E.

Arif E. Cetin, Alket Mertiri, Shyamsunder Erramilli, and Hatice Altug. Thermal Tuning of Surface Plasmon Polaritons Using Liquid Crystal. ADVANCED OPTICAL MATERIALS. 2013 December; 1 (12): 915-920. doi:10.1002/adom.201300303.

Arif E. Cetin, Mustafa Turkmen, Serap Aksu, and Hatice Altug. Nanoparticle-Based Metamaterials as Multiband Plasmonic Resonator Antennas. IEEE TRANSACTIONS ON NANOTECHNOLOGY. 2012 January; 11 (1): 208 - 212. doi:10.1109/TNANO.2011.2174160.

Arif E. Cetin, Ahmet Ali Yanik, Alket Mertiri, Shyamsunder Erramilli, Ozgur E. Mustecaplioglu, and Hatice Altug. Field-Effect Active Plasmonics for Ultracompact Electro-Optic Switching. APPLIED PHYSICS LETTERS. 2012 September; 101 (12): 121113. doi:10.1063/1.4754139.

Arif E. Cetin, and Hatice Altug. Fano Resonant Ring/Disk Plasmonic Nanocavities on Conducting Substrates for Advanced Biosensing. ACS NANO. 2012 October; 6 (11): 9989-9995. doi:10.1021/nn303643w.

Ahmet Ali Yanik, Arif E. Cetin, Min Huang, Alp Artar, S. Hossein Mousavi, Alexander Khanikaev, John H. Connor, Gennady Shvets, and Hatice Altug. Seeing Protein Monolayers with Naked Eye Through Plasmonic Fano Resonances. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2011 February; 108 (29): 11784-11789. doi:10.1073/pnas.1101910108.

Arif E. Cetin, Alp Artar, Mustafa Turkmen, Ahmet Ali Yanik, and Hatice Altug. Plasmon Induced Transparency in Cascaded π-Shaped Metamaterials. OPTICS EXPRESS. 2011 October; 19 (23): 22607-22618. doi:10.1364/OE.19.022607.

Arif E. Cetin, Ahmet Ali Yanik, Cihan Yilmaz, Sivasubramanian Somu, Ahmed Busnaina, and Hatice Altug. Monopole Antenna Arrays for Optical Trapping, Spectroscopy, and Sensing. APPLIED PHYSICS LETTERS. 2011 February; 98 (111110): 1-3. doi:10.1063/1.3559620.

Mustafa Turkmen, Serap Aksu, Arif E. Cetin, Ahmet Ali Yanik, and Hatice Altug. Multi-Resonant Metamaterials Based on UT-Shaped Nano-Aperture Antenna. OPTICS EXPRESS. 2011 April; 19 (8): 7921-7928. doi:10.1364/OE.19.007921.

Arif E. Cetin, Alphan Sennaroglu, and Ozgur E. Mustecaplioglu. Nanoscale plasmonic devices for dynamically controllable beam focusing and scanning. PHOTONICS AND NANOSTRUCTURES-FUNDAMENTALS AND APPLICATIONS. 2010 January; 8 (1): 7-13. doi:10.1016/j.photonics.2009.12.001.

Arif E. Cetin, and Ozgur E. Mustecaplioglu. Electrically tunable Dicke effect in a double-ring resonator. PHYSICAL REVIEW A. 2010 April; 81 (4): 043812. doi:10.1103/PhysRevA.81.043812.

Arif E. Cetin, K. Guven, and Ozgur E. Mustecaplioglu. Active Control of Focal Length and Beam Deflection in a Metallic Nano-Rod Lens System with Multiple Sources. OPTICS LETTERS. 2010 June; 35 (12): 1980-1982. doi:10.1364/OL.35.001980.

Total: 39

Selected Book Chapters

Overcoming Mass-Transport Limitations with Optofluidic Plasmonic Biosensors and Particle Trapping (2012). Optochemical Nanosensors. Taylor and Francis.

Total: 1

Awards

  • - Young Scientist (BAGEP) Award by , 2019

Contact

Cetin Lab.

Director

ARIF ENGIN ÇETİN
arifengin.cetin@ibg.edu.tr
+90 232 299 41 00 (5161)
+9 02322994166