Küçük Lab. on Lymphoid Cancer Genomics

RESEARCH INTERESTS

ur current research mainly focuses on the identification and characterization of novel mutations and epigenetic alterations of tumor suppressor genes or oncogenes in lymphoid cancers. Our interest mainly resides in lymphomas (e.g. follicular lymphoma) and other lymphoid cancers (e.g. multiple myeloma) which are neoplastic diseases having a high degree of genetic heterogeneity.

We frequently use next generation sequencing (NGS) based technologies (e.g. WES, RNA-Seq, targeted NGS) to generate a candidate list of aberrant genes using panels of lymphoma patient samples. We then cross-validate mutations that are identified through NGS methodologies by applying Sanger sequencing. Moreover, our studies focus on genome-wide or loci-specific methylation changes in cancer samples. Altogether, we characterize these aberrations using a combination of genetic, epigenetic and molecular biology assays. In general, our studies follow a wholistic approach which involves the cooperation of a variety interrelated biomedical disciplines such as pathology, functional genomics, and computational bioinformatics. Our eventual goal is to identify and characterize genetic and epigenetic abnormalities in individual cancer patients to translate the discoveries as personalized medicine.

Group Members

Küçük Lab. on Lymphoid Cancer Genomics

Group Leader

Can KÜÇÜK
can.kucuk@ibg.edu.tr
+90 232 299 41 00 (5011)
+9 02322994151

AYLA ANAR Technician  ayla.anar@ibg.edu.tr


Burcu AKMAN Ph.D. Student  burcu.akman@msfr.ibg.edu.tr


Deniz KURŞUN MSc Student  deniz.kursun@msfr.ibg.edu.tr


Tevfik HATİPOĞLU Ph.D. Student  tevfik.hatipoglu@msfr.ibg.edu.tr


Esra ESMERAY Ph.D. Student  esra.esmeray@msfr.ibg.edu.tr


Contact

Küçük Lab. on Lymphoid Cancer Genomics

Group Leader

Can KÜÇÜK
can.kucuk@ibg.edu.tr
+90 232 299 41 00 (5011)
+9 02322994151