Hepatocellular cancers can be sub-grouped into hepatocellular carcinomas (HCCs) and cholangiocarcinomas that affect mostly adults, and childhood hepatoblastomas. HCCs are the third most common cause of death from cancer, with more than one million patients dying worldwide each year. These tumors show extreme heterogeneity in their genomic aberrations and their epigenetic status is ill-defined. They are naturally resistant to chemotherapy and radiotherapy and the five-year survival rate of affected patients is very low. In order to discover new targets and new anti-tumor drugs, it is important to better characterize molecular mechanisms of hepatocellular cancers.
Our most recent findings concern senescence-related events associated with hepatocellular cancer cell immortalization. We used genome-wide expression analysis to identify sets of genes whose expression is associated with either senescence and cirrhosis or immortality and hepatocellular carcinoma. Surprisingly, a large number of gene sets were affected (Ozturk et al., PNAS 2006, Yildiz et al. PLoS ONE, 2013). We identified a gene signature that allowed us to differentiate HCC from cirrhosis (Yildiz et al. PLoS ONE 2013). More interestingly, we also identified another gene signature with an excellent prediction of patient survival (PATENT PENDING PCT/EP2014/058293).
Within the scope of TUBITAK 1003 project titled “Development and Production of Lung Cancer Monoclonal Antibodies Commonly Used in Clinical Pathology”, 2 personnel and 3 postdoctoral researchers will be recruited to İzmir Biomedicine and Genome Center.
Required and preferred qualifications for personnel
• Bachelor's degree in Molecular Biology and Genetics, Biology, Bioengineering or any other related fields is required
• Experience in molecular biology laboratory techniques is required
• Experience in hybridoma, phage display, immunohistochemistry, antibody production, cancer biology, pathology and/or biochemistry is preferred
Required and preferred qualifications for postdoctoral researchers
• PhD degree in Molecular Biology and Genetics, Biology, Bioengineering or any other related fields is required
• Strong knowledge about molecular biology laboratory techniques is required
• Experience in at least one of following fields is required: hybridoma, phage display, immunohistochemistry and/or antibody production
Interested applicants should send their CV to email@example.com by November 15, 2019.