Hepatocellular cancers can be sub-grouped into hepatocellular carcinomas (HCCs) and cholangiocarcinomas that affect mostly adults, and childhood hepatoblastomas. HCCs are the third most common cause of death from cancer, with more than one million patients dying worldwide each year. These tumors show extreme heterogeneity in their genomic aberrations and their epigenetic status is ill-defined. They are naturally resistant to chemotherapy and radiotherapy and the five-year survival rate of affected patients is very low. In order to discover new targets and new anti-tumor drugs, it is important to better characterize molecular mechanisms of hepatocellular cancers.
Our most recent findings concern senescence-related events associated with hepatocellular cancer cell immortalization. We used genome-wide expression analysis to identify sets of genes whose expression is associated with either senescence and cirrhosis or immortality and hepatocellular carcinoma. Surprisingly, a large number of gene sets were affected (Ozturk et al., PNAS 2006, Yildiz et al. PLoS ONE, 2013). We identified a gene signature that allowed us to differentiate HCC from cirrhosis (Yildiz et al. PLoS ONE 2013). More interestingly, we also identified another gene signature with an excellent prediction of patient survival (PATENT PENDING PCT/EP2014/058293).
Senem Demir, Cigdem Özen, Meltem Ceylan‐Ünlüsoy, Mehmet Öztürk, Oya Bozdağ‐Dündar. Novel Furochromone Derivatives: Synthesis and Anticancer Activity Studies. Journal of Heterocyclic Chemistry. 2019 February. doi:10.1002/jhet.3508.
Ozen C, Ceylan-Unlusoy M, Ozturk M, Bozdag-Dundar O.. A novel chromonyl thiohydantoin with anti-proliferative action on primary hepatocellular carcinoma cells. Med Chem Res. 2018 January; 27 (1): 153-160. doi:10.1007/s00044-017-2037-0.
Avci ME, Keskus AG, Targen S, Isilak ME, Ozturk M, Atalay RC, Adams MM, Konu O. Development of a novel zebrafish xenograft model in ache mutants using liver cancer cell lines. Scientific Reports. 2018 January; 8 (1): 1570. doi:10.1038/s41598-018-19817-w.
Ors A, Papin C, Favier B, Roulland Y, Dalkara D, Ozturk M, Hamiche A, Dimitrov S, Padmanabhan K.. Histone H3.3 regulates mitotic progression in mouse embryonic fibroblasts. Biochem Cell Biol. 2017 August; 95 (4): 491-499. doi:10.1139/bcb-2016-0190.
Ozturk M, Batur T, Ekin U, Erdogan A, İscan E, Keles U, Oz O, Ozen C.. Molecular Pathogenesis of Liver Cancer. J Gastrointest Cancer. 2017 July. doi:10.1007/s12029-017-9957-2.
Cigdem Ozen, Meltem Ceylan Unlusoy, Nazanin Aliary, Mehmet Ozturk, Oya Bozdag Dundar.. Thiazolidinedione or Rhodanine: A Study on Synthesis and Anticancer Activity Comparison of Novel Thiazole Derivatives. J Pharm Sci. 2017 November; 20 (1): 415-427. doi:10.18433/J38P9R.