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BASIC AND TRANSLATIONAL RESEARCH PROGRAM
Alotaibi Lab. Angelov Lab. Atabey Lab. Dimitrov Lab. Erkek Lab. Gene Targeting and Transgenic Models Platform Genc Lab. Kale Lab. Karaca Lab. Kucuk Lab. Oktay Lab. Ozhan Lab. Pavlopoulou Lab. Sag Lab. Senturk Lab. Wingender Lab.

Sag Lab. on Cancer Immunology

OVERVIEW

Metabolic and immune responses are the most basic and important survival requirements in multicellular organisms. Recent studies by us and others have uncovered the strong mutual influence of metabolism and macrophage inflammatory responses. Identifying the underlying mechanisms is a fascinating and vibrant novel research area and its findings will be critical for the design of therapeutic treatments for both metabolic and inflammatory diseases.

Group Members

Sag Lab. on Cancer Immunology

Research Group Leader

Duygu SAĞ
duygu.sag@ibg.edu.tr
+90 232 299 41 00 (5021)

  1. Sag Lab. on Cancer Immunology

Sinem GÜNALP PhD Student  sinem.gunalp@msfr.ibg.edu.tr


Yonca ERDAL Technician  yonca.erdal@ibg.edu.tr


Aslı KORKMAZ PhD Student  asli.korkmaz@msfr.ibg.edu.tr


Derya Göksu HELVACI Undergraduate Student  deryagoksu.helvaci@msfr.ibg.edu.tr


Duygu ÜNÜVAR PURCU PhD Student  duygu.unuvar@msfr.ibg.edu.tr


Resul ÖZBİLGİÇ MSc Student  resul.ozbilgic@msfr.ibg.edu.tr


Selected Publications

Sag D, Ayyildiz ZO, Gunalp S, Wingender G. The Role of TRAIL/DRs in the Modulation of Immune Cells and Responses.. Cancers. 2019 September ; 11 (10) : 1469. doi:10.3390/cancers11101469.

Duygu Sag, Müge Özkan, Mitchell Kronenberg & Gerhard Wingender. Improved Detection of Cytokines Produced by Invariant NKT Cells. Sci Rep. 2017 November ; 7 (1) : 16607. doi:10.1038/s41598-017-16832-1.

Wingender G, Sag D, Kronenberg M. NKT10 cells: a novel iNKT cell subset. Oncotarget. 2015 September ; 6 (29) : 26552-26553. doi:10.18632/oncotarget.5270.

Wingender, Gerhard; Birkholz, Alysia M.; Sag, Duygu; Farber, Elisa; Chitale, Sampada; Howell, Amy R.; Kronenberg, Mitchell. Selective Conditions Are Required for the Induction of Invariant NKT Cell Hyporesponsiveness by Antigenic Stimulation. JOURNAL OF IMMUNOLOGY. 2015 October ; 195 (8) : 3838-3848. doi:10.4049/jimmunol.1500203.

Hanna, Richard N.; Cekic, Caglar; Sag, Duygu; Tacke, Robert; Thomas, Graham D.; Nowyhed, Heba; Herrley, Erica; Rasquinha, Nicole; McArdle, Sara; Wu, Runpei; Peluso, Esther; Metzger, Daniel; Ichinose, Hiroshi; Shaked, Iftach; Chodaczek, Grzegorz; Biswas, Subhra K.; Hedrick, Catherine C.. Patrolling monocytes control tumor metastasis to the lung. SCIENCE. 2015 November ; 350 (6263) : 985-990. doi:10.1126/science.aac9407.

Total : 5

Projects

The Scientific and Technological Research Council of Turkey (TUBITAK) - RD : Role Of The Cholesterol Transporter ABCG1 İn Tumor-Associated Macrophages In Mice And Humans

European Union - RD : Death Receptor Signalling in Tumour Immune Editing

The Scientific and Technological Research Council of Turkey (TUBITAK) - RD : The Impact of TRAIL on M1, M2a and M2c Polarization of Primary Human Macrophages

The Scientific and Technological Research Council of Turkey (TUBITAK) - RD : Generation of Osteogenic Niche Under Dynamic Culture Conditions with Microfluidic Bioreactors

The Scientific and Technological Research Council of Turkey (TUBITAK) - RD : Kornea Endoteli Dokusunun Kök Hücre ve Biyomühendislik Yaklasımlarıyla Geliştirilmesi

The Scientific and Technological Research Council of Turkey (TUBITAK) - RD : Küçük Hücreli Akciğer Kanserine Karşı Kişiye Yönelik Tedavi Geliştirmek için Hastalardan Türetilen Zenograftların Model Olarak Kullanılması

DEÜ BAP - Dokuz Eylul University Scientific Research Projects Coordination Unit - RD : Kolestrolün Makrofaj Polarizasyonuna Etkisi ve Mekanizması

The Science Academy - RD : The Impact of ABCG1 Expression in Macrophages on Macrophage Phenotype and Development of Bladder Cancer in Humans

L'Oreal UNESCO Turkey - RD : The Molecular Mechanism of the Switch of ABCG1-deficient Macrophages Towards a Tumor-Fighting M1 Phenotype

L'Oreal UNESCO International - RD : The Molecular Mechanism of the Switch of ABCG1-deficient Macrophages Towards a Tumor-Fighting M1 Phenotype

Turkish Academy of Sciences (TÜBA) - RD : Investigation of ATP-binding Cassette Transporter G1 in Human Macrophages as a Candidate Target Molecule for Immunotherapy

Awards

  • METU Parlar Foundation Research Incentive Award by METU Prof. Mustafa N. Parlar Education and Research Foundation, 2019
  • International Rising Talent Award by L'Oréal UNESCO, 2018
  • Young Scientist (BAGEP) Award by Science Academy, 2018
  • Young Investigator (GEBİP) Awards by Turkish Academy of Sciences (TÜBA), 2018
  • Işıl Berat Barlan Women Scientist Award by Turkish Society of Immunology, 2017
  • L’Oréal & UNESCO Turkey National Women in Science Award by L'Oréal UNESCO, 2017
  • International Rising Talents Candidate of Turkey by L'Oréal UNESCO, 2017
  • 2236 Co-Funded Brain Circulation Scheme by Marie Curie, 2015

Contact

Sag Lab. on Cancer Immunology

Research Group Leader

Duygu SAĞ
duygu.sag@ibg.edu.tr
+90 232 299 41 00 (5021)