Sag Lab. on Cancer Immunology

OVERVIEW

Metabolic and immune responses are the most basic and important survival requirements in multicellular organisms. Recent studies by us and others have uncovered the strong mutual influence of metabolism and macrophage inflammatory responses. Identifying the underlying mechanisms is a fascinating and vibrant novel research area and its findings will be critical for the design of therapeutic treatments for both metabolic and inflammatory diseases.

Group Members

Sag Lab. on Cancer Immunology

Research Group Leader

Duygu SAĞ
duygu.sag@ibg.edu.tr
+90 232 299 41 00 (5021)
+9 0 232 299 41 52

Duygu ÜNÜVAR PURCU Research Assistant  duygu.unuvar@ibg.edu.tr


Ayşenur ÖNER MSc Student  aysenur.oner@ibg.edu.tr


Aslı KORKMAZ PhD Student  asli.korkmaz@ibg.edu.tr


Sinem GÜNALP PhD Student  sinem.gunalp@ibg.edu.tr


Resul ÖZBİLGİÇ MSc Student  resul.ozbilgic@ibg.edu.tr


Derya Göksu HELVACI Undergraduate Student  deryagoksu.helvaci@ibg.edu.tr


Former Members

Derya Göksu HELVACI Undergraduate Student  deryagoksu.helvaci@ibg.edu.tr


Duygu ÜNÜVAR PURCU PhD Student  duygu.unuvar@ibg.edu.tr


Meltem ALTUNAY MSc Student  meltem.altunay@msfr.ibg.edu.tr


Selected Publications

Sag D, Ayyildiz ZO, Gunalp S, Wingender G. The Role of TRAIL/DRs in the Modulation of Immune Cells and Responses.. Cancers. 2019 September ; 11 (10) : 1469. doi:10.3390/cancers11101469. Download

Duygu Sag, Müge Özkan, Mitchell Kronenberg & Gerhard Wingender. Improved Detection of Cytokines Produced by Invariant NKT Cells. Sci Rep. 2017 November ; 7 (1) : 16607. doi:10.1038/s41598-017-16832-1. Download

Wingender G, Sag D, Kronenberg M. NKT10 cells: a novel iNKT cell subset. Oncotarget. 2015 September ; 6 (29) : 26552-26553. doi:10.18632/oncotarget.5270. Download

Wingender, Gerhard; Birkholz, Alysia M.; Sag, Duygu; Farber, Elisa; Chitale, Sampada; Howell, Amy R.; Kronenberg, Mitchell. Selective Conditions Are Required for the Induction of Invariant NKT Cell Hyporesponsiveness by Antigenic Stimulation. JOURNAL OF IMMUNOLOGY. 2015 October ; 195 (8) : 3838-3848. doi:10.4049/jimmunol.1500203. Download

Hanna, Richard N.; Cekic, Caglar; Sag, Duygu; Tacke, Robert; Thomas, Graham D.; Nowyhed, Heba; Herrley, Erica; Rasquinha, Nicole; McArdle, Sara; Wu, Runpei; Peluso, Esther; Metzger, Daniel; Ichinose, Hiroshi; Shaked, Iftach; Chodaczek, Grzegorz; Biswas, Subhra K.; Hedrick, Catherine C.. Patrolling monocytes control tumor metastasis to the lung. SCIENCE. 2015 November ; 350 (6263) : 985-990. doi:10.1126/science.aac9407. Download

Sag D, Cekic C, Wu R, Linden J, Hedrick CC. The cholesterol transporter ABCG1 links cholesterol homeostasis and tumour immunity.. Nature communications. 2015 February ; 6 : 6354. doi:10.1038/ncomms7354. Download

Zhu YP, Brown JR, Sag D, Zhang L, Suttles J. Adenosine 5'-monophosphate-activated protein kinase regulates IL-10-mediated anti-inflammatory signaling pathways in macrophages.. Journal of immunology (Baltimore, Md. : 1950). 2015 January ; 194 (2) : 584-94. doi:10.4049/jimmunol.1401024. Download

Sag D, Krause P, Hedrick CC, Kronenberg M, Wingender G. IL-10-producing NKT10 cells are a distinct regulatory invariant NKT cell subset.. The Journal of clinical investigation. 2014 September ; 124 (9) : 3725-40. doi:10.1172/JCI72308. Download

Cekic C, Day YJ, Sag D, Linden J. Myeloid expression of adenosine A2A receptor suppresses T and NK cell responses in the solid tumor microenvironment.. Cancer research. 2014 December ; 74 (24) : 7250-9. doi:10.1158/0008-5472.CAN-13-3583. Download

Cekic C, Sag D, Day YJ, Linden J. Extracellular adenosine regulates naive T cell development and peripheral maintenance.. The Journal of experimental medicine. 2013 November ; 210 (12) : 2693-706. doi:10.1084/jem.20130249. Download

Cekic C, Sag D, Li Y, Theodorescu D, Strieter RM, Linden J. Adenosine A2B receptor blockade slows growth of bladder and breast tumors.. Journal of immunology (Baltimore, Md. : 1950). 2012 January ; 188 (1) : 198-205. doi:10.4049/jimmunol.1101845. Download

Sag D, Wingender G, Nowyhed H, Wu R, Gebre AK, Parks JS, Kronenberg M, Hedrick CC. ATP-binding cassette transporter G1 intrinsically regulates invariant NKT cell development.. Journal of immunology (Baltimore, Md. : 1950). 2012 December ; 189 (11) : 5129-38. doi:10.4049/jimmunol.1201570. Download

Cekic C, Casella CR, Sag D, Antignano F, Kolb J, Suttles J, Hughes MR, Krystal G, Mitchell TC. MyD88-dependent SHIP1 regulates proinflammatory signaling pathways in dendritic cells after monophosphoryl lipid A stimulation of TLR4.. Journal of immunology (Baltimore, Md. : 1950). 2011 April ; 186 (7) : 3858-65. doi:10.4049/jimmunol.1001034. Download

Sag D, Carling D, Stout RD, Suttles J. Adenosine 5'-monophosphate-activated protein kinase promotes macrophage polarization to an anti-inflammatory functional phenotype.. Journal of immunology (Baltimore, Md. : 1950). 2008 December ; 181 (12) : 8633-41. doi:10.4049/jimmunol.181.12.8633. Download

Total : 14

Projects

The Scientific and Technological Research Council of Turkey - TUBITAK - RD : Role Of The Cholesterol Transporter ABCG1 İn Tumor-Associated Macrophages In Mice And Humans, Finished

European Union - RD : Death Receptor Signalling in Tumour Immune Editing, Ongoing

The Scientific and Technological Research Council of Turkey - TUBITAK - RD : The Impact of TRAIL on M1, M2a and M2c Polarization of Primary Human Macrophages, Ongoing

The Scientific and Technological Research Council of Turkey - TUBITAK - RD : Generation of Osteogenic Niche Under Dynamic Culture Conditions with Microfluidic Bioreactors, Ongoing

The Scientific and Technological Research Council of Turkey - TUBITAK - RD : Kornea Endoteli Dokusunun Kök Hücre ve Biyomühendislik Yaklasımlarıyla Geliştirilmesi, Ongoing

The Scientific and Technological Research Council of Turkey - TUBITAK - RD : Küçük Hücreli Akciğer Kanserine Karşı Kişiye Yönelik Tedavi Geliştirmek için Hastalardan Türetilen Zenograftların Model Olarak Kullanılması, Ongoing

DEÜ BAP - Dokuz Eylul University Scientific Research Projects Coordination Unit - RD : Kolestrolün Makrofaj Polarizasyonuna Etkisi ve Mekanizması, Finished

Science Academy - RD : The Impact of ABCG1 Expression in Macrophages on Macrophage Phenotype and Development of Bladder Cancer in Humans, Finished

L'Oreal UNESCO Turkey - RD : The Molecular Mechanism of the Switch of ABCG1-deficient Macrophages Towards a Tumor-Fighting M1 Phenotype, Finished

L'Oreal UNESCO International - RD : The Molecular Mechanism of the Switch of ABCG1-deficient Macrophages Towards a Tumor-Fighting M1 Phenotype, Finished

Turkish Academy of Sciences (TÜBA) - RD : Investigation of ATP-binding Cassette Transporter G1 in Human Macrophages as a Candidate Target Molecule for Immunotherapy, Ongoing

Patents

  • Duygu Sag, Erdal Bedir, Ali Cagir, Nilgun Yakubogullari , SAPONİN MOLEKÜLLERİNİN ELDESİ İÇİN BİR YÖNTEM VE AKTİF MOLEKÜLLERİN İMMÜNOMODÜLATÖR OLARAK KULLANIMI, None

Awards

  • 2020 Woman Making a Difference Award by Bursa Businesswomen and Executives Association (BUIKAD), 2020
  • Best Poster Award-Asli Korkmaz by Turkish Society of Immunology, 2020
  • Best Poster Award-Duygu Unuvar Purcu by Turkish Society of Immunology, 2020
  • METU Parlar Foundation Research Incentive Award by METU Prof. Mustafa N. Parlar Education and Research Foundation, 2019
  • Best Paper Award by Trailblazers in Oncology Summit, 2019
  • International Rising Talent Award by L'Oréal UNESCO, 2018
  • Young Scientist (BAGEP) Award by Science Academy, 2018
  • Young Investigator (GEBİP) Awards by Turkish Academy of Sciences (TÜBA), 2018
  • Işıl Berat Barlan Women Scientist Award by Turkish Society of Immunology, 2017
  • L’Oréal & UNESCO Turkey National Women in Science Award by L'Oréal UNESCO, 2017
  • International Rising Talents Candidate of Turkey by L'Oréal UNESCO, 2017
  • 2236 Co-Funded Brain Circulation Scheme by Marie Curie, 2015

Contact

Sag Lab. on Cancer Immunology

Research Group Leader

Duygu SAĞ
duygu.sag@ibg.edu.tr
+90 232 299 41 00 (5021)
+9 0 232 299 41 52