Dr. Serap Erkek's study has been published in Cancer Cell journal
In a recent study entitled as ‘Comprehensive Analysis of Chromatin States in Atypical Teratoid/Rhabdoid Tumor Identifies Diverging Roles for SWI/SNF and Polycomb in Gene Regulation’ published in Cancer Cell on 27th December 2018, Dr. Serap Erkek from IBG and her colleagues identified differential activities of SWI/SNF and Polycomb complexes in regulation of diverse gene sets in atypical teratoid rhabdoid tumors (ATRT). ATRT is a tumor mainly seen in children younger than 3 years old and characterized by inactivation of SMARCB1, a component of SWI/SNF remodeler complex. Identification of the role of SMARCB1 in ATRT tumorigenesis is highly critical. Results from Erkek et al. provide critical insights about design of therapies targeting SWI/SNF components alone or in combination with inhibition of Polycomb group proteins.